PXD066892 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Arabidopsis thaliana_Col-0_ces-qM_0and7dpi_Hpa |
| Description | When organisms encounter pathogens, they rapidly activate complex defense programs to ensure survival. While these immune responses are vital, they often also incur trade-offs, such as reduced growth and development and must therefore be tightly controlled. In this study, we reveal that the steroid hormones brassinosteroids (BRs) contribute to this control in Arabidopsis thaliana by repressing immunity-related genes. We provide evidence that the BR-regulated basic helix-loop-helix (bHLH) transcription factor CESTA (CES), along with its homologs BR ENHANCED EXPRESSION (BEE)1-3, mediate DNA methylation changes at transposable element (TE)-rich loci containing nucleotide-binding leucine-rich-repeat (NLR)-type receptor genes, including SUPPRESSOR OF NPR1-1 CONSTITUTIVE 1 (SNC1). These CES-induced methylation changes correlate with altered splicing of SNC1 pre-mRNA, a process that requires the BR receptor BRASSINOSTEROID INSENSITIVE 1 (BRI1). In support, we show that CES associates with components of the chromatin remodeling and splicing machinery. Together, our findings reveal a previously unrecognized BR-induced mechanism that modulates the epigenetic and post transcriptional regulation of immune genes, enabling plants to prioritize growth over defense. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-08-03 |
| AnnouncementXML | Submission_2026-08-03_01:09:23.166.xml |
| DigitalObjectIdentifier | https://doi.org/10.6019/PXD066892 |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Veronica Ramirez |
| SpeciesList | scientific name: Arabidopsis thaliana (Mouse-ear cress); NCBI TaxID: NEWT:3702; |
| ModificationList | acetylated residue; iodoacetamide derivatized residue |
| Instrument | Orbitrap Fusion Lumos |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-08-03 11:04:25 | ID requested | |
| ⏵ 1 | 2026-08-03 01:09:23 | announced | |
Publication List
Keyword List
| submitter keyword: Arabidopsis thaliana, CESTA, Hpa |
Contact List
| Prof. Dr. Brigitte Poppenberger |
|---|
| contact affiliation | Biotechnology of Horticultural Crops, Technical University of Munich |
| contact email | brigitte.poppenberger@tum.de |
| lab head | |
| Veronica Ramirez |
|---|
| contact affiliation | Technical University of Munich |
| contact email | veronicae.ramirez@tum.de |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
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| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD066892
- Label: PRIDE project
- Name: Arabidopsis thaliana_Col-0_ces-qM_0and7dpi_Hpa
