PXD066868-1

PXD066868 is an original dataset announced via ProteomeXchange.

Title	Proteomics of post-mortem brains in early and late-onset Alzheimer's disease: unraveling differential Aβ effects and potential AD biomarkers_library
Description	Alzheimer’s disease (AD) is the most common form of neurodegeneration presented mainly as late-onset AD (LOAD), and in younger individuals early-onset AD (EOAD). The pathological hallmarks of AD are the hyperphosphorylated tau neurofibrillary tangles and the amyloid beta (Aβ) plaques. We examined changes in the proteome of post-mortem temporal cortex from individuals with EOAD and LOAD, and revealed that EOAD represents a more aggressive form of the disease. Notably, we observed up-regulation of AD biomarkers p-tau181, p-tau217, and p-tau23, and tau MTBR243, in AD tissues. Two abundant tau peptides phosphorylated at p-231/p-235 and p-231/p-235/p-237 were present largely in AD tissues, which may be developed as biomarkers. Aβ was detected in about half of the cognitively unimpaired elderly controls with subtle proteome changes that resembled in part the changes of biological processes in AD. This could indicate an early stage of neurodegeneration preceding clinical AD symptoms or represent an AD-resilient state.
HostingRepository	PRIDE
AnnounceDate	2026-07-13
AnnouncementXML	Submission_2026-07-13_02:32:43.955.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Evangelia Thanou
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	N6-methyl-L-lysine; phosphorylated residue; acetylated residue; monohydroxylated residue; N6; iodoacetic acid derivatized residue; N6
Instrument	timsTOF Pro 2

Revision	Datetime	Status	ChangeLog Entry
0	2025-08-01 13:07:44	ID requested
⏵ 1	2026-07-13 02:32:44	announced

10.1002/ALZ.71662;

submitter keyword: brain proteomics, LOAD, app, PTMs, Alzheimer's, AD, Abeta, mapt, post--mortem, EOAD

Ka Wan
contact affiliation	Department of Molecular and Cellular Neurobiology, Center for Neurogenomics & Cognitive Research, Neuroscience Campus Amsterdam, VU University, Amsterdam, The Netherlands
contact email	k.w.li@vu.nl
lab head
Evangelia Thanou
contact affiliation	Center for Neurogenomics and Cognitive Research, Department of Molecular and Cellular Neurobiology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands.
contact email	e.thanou@vu.nl
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/07/PXD066868

PRIDE project URI

• PRIDE
  1. PXD066868
     1. Label: PRIDE project
     2. Name: Proteomics of post-mortem brains in early and late-onset Alzheimer's disease: unraveling differential Aβ effects and potential AD biomarkers_library