PXD066837-1

PXD066837 is an original dataset announced via ProteomeXchange.

Title	Gut Bacteria Influence on Ovarian Proteomics in Bactrocera dorsalis
Description	The gut microbiota is considered the host's "second genome" and is closely associated with the host's physiology. We found that the elimination of gut bacteria suppressed ovarian development in Bactrocera dorsalis. Proteomic analysis revealed significant differences in ovarian protein expression after gut bacteria depletion, with differentially expressed proteins enriched in the proteasome and ubiquitin-related pathway. Moreover, ubiquitination levels were significantly reduced in gut bacteria-depleted females, while Enterobacter hormaechei (EH) supplementation rescued ubiquitination levels. Our findings suggest that ubiquitination serves as a mediator through which gut bacteria regulate ovarian development. By ubiquitin-modified proteomic analysis following gut microbiota manipulation and EH supplementation, we aimed to identify ubiquitination targets critical for ovarian development.
HostingRepository	iProX
AnnounceDate	2025-08-01
AnnouncementXML	Submission_2025-08-31_20:33:16.188.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jiao Qiao
SpeciesList	scientific name: Bactrocera dorsalis; NCBI TaxID: 27457;
ModificationList	ubiquitination signature dipeptidyl lysine
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2025-07-31 21:07:48	ID requested
⏵ 1	2025-08-31 20:33:16	announced

Dataset with its publication pending

submitter keyword: Gut bacteria, Bactrocera dorsalis, proteomics, ovarian development

Hongyu Zhang
contact affiliation	Huazhong Agricultural University
contact email	hongyu.zhang@mail.hzau.edu.cn
lab head
Jiao Qiao
contact affiliation	Huazhong Agricultural University
contact email	Qiaoj7422@163.com
dataset submitter

iProX dataset URI