PXD066828 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Iron depletion proteomics of Toxoplasma tachyzoites |
| Description | Iron is essential for almost all life as a result of its vital role as a protein cofactor. Toxoplasma must obtain iron from their host cells, but these host cells can employ strategies to restrict pathogen access to this essential nutrient. Here we use quantitative proteomics of Toxoplasma tachyzoites grown for 24 hours in control or iron depleted conditions to understand proteomic adaptation to low iron conditions. We find that iron deprived parasites remodel their proteome profoundly in response to iron depletion, including the downregulation of much of the machinery involved in protein translation. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-03-18 |
| AnnouncementXML | Submission_2026-03-18_03:25:19.910.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Jack Hanna |
| SpeciesList | scientific name: Toxoplasma gondii GT1; NCBI TaxID: NEWT:507601; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive HF |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-07-31 16:01:30 | ID requested | |
| ⏵ 1 | 2026-03-18 03:25:20 | announced | |
Publication List
Keyword List
| submitter keyword: DIA,Iron depletion |
Contact List
| Clare R Harding |
|---|
| contact affiliation | Glasgow Centre for Parasitology, School of Infection and Immunity, University of Glasgow, Glasgow, UK |
| contact email | clare.harding@glasgow.ac.uk |
| lab head | |
| Jack Hanna |
|---|
| contact affiliation | University of Glasgow |
| contact email | jack.hanna@glasgow.ac.uk |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/03/PXD066828 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD066828
- Label: PRIDE project
- Name: Iron depletion proteomics of Toxoplasma tachyzoites
