PXD066806 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Age-dependent protein changes in replicatively aged budding yeast. |
| Description | Using budding yeast replicative lifespan as a model for aging in actively dividing cells, we identified nuclear proteins that were increased or depleted in the earliest stages of aging. We performed a proteomic screen comparing isolated nuclei from young (~0-2 generations) versus moderately aged (~6-7 generations) yeast cells (diploid lab strain BY4743) that were isolated from mini-chemostat aging devices. We found that many age-depleted proteins were involved in ribosome biogenesis, specifically in ribosome processing, or in maintenance of chromatin stability. Many proteins that were significantly upregulated in the early stages of aging were involved in the maintenance of cellular homeostasis, including metabolic processes such as carbohydrate, glucan, NADH, and ethanol metabolism. |
| HostingRepository | PRIDE |
| AnnounceDate | 2025-12-01 |
| AnnouncementXML | Submission_2025-12-01_13:50:45.217.xml |
| DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD066806 |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Lindsey Power |
| SpeciesList | scientific name: Saccharomyces cerevisiae (Baker's yeast); NCBI TaxID: NEWT:4932; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-07-31 07:32:19 | ID requested | |
| ⏵ 1 | 2025-12-01 13:50:45 | announced | |
Publication List
Keyword List
| submitter keyword: Yeast, replicative aging, nuclei |
Contact List
| Jeffrey Smith |
|---|
| contact affiliation | University of Virginia School of Medicine |
| contact email | jss5y@virginia.edu |
| lab head | |
| Lindsey Power |
|---|
| contact affiliation | University of Virginia |
| contact email | lnp9pn@virginia.edu |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/12/PXD066806 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD066806
- Label: PRIDE project
- Name: Age-dependent protein changes in replicatively aged budding yeast.
