PXD066792-1

PXD066792 is an original dataset announced via ProteomeXchange.

Title	Circulating Proteins and Metabolites Panel for Noninvasive Preoperative Diagnosis of Epithelial Ovarian Cancer
Description	Plasma was collected from 251 participants, including patients with EOC (n = 97), borderline ovarian tumors (n = 38), benign ovarian tumors (n = 54), and healthy controls (n = 62). Proteomic and metabolomic profiling was performed. A machine learning model was trained on a training cohort (34 EOC patients and 62 non-OC individuals [borderline, benign, and healthy controls]) to distinguish EOC from other groups. The model was validated in two independent cohorts: validation cohort 1 (n = 25) and validation cohort 2 (n = 130) using targeted proteomics and untargeted metabolomics.
HostingRepository	iProX
AnnounceDate	2025-07-31
AnnouncementXML	Submission_2025-07-31_21:14:17.183.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Shuzhong Yao
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2025-07-31 01:13:04	ID requested
⏵ 1	2025-07-31 21:14:17	announced

Dataset with its publication pending

submitter keyword: Proteome, Metabolome, EOC, Diagnosis, Differential diagnosis

Shuzhong Yao
contact affiliation	Department of Obstetrics and Gynecology, The First Affiliated Hospital, Sun Yat-sen University
contact email	yaoshuzh@mail.sysu.edu.cn
lab head
Shuzhong Yao
contact affiliation	Department of Obstetrics and Gynecology, The First Affiliated Hospital, Sun Yat-sen University
contact email	yaoshuzh@mail.sysu.edu.cn
dataset submitter

iProX dataset URI