PXD066738-1
PXD066738 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Characterization of the Anti-Alzheimer Drug Lecanemab by Mass Spectrometry |
| Description | Lecanemab is a humanized immunoglobulin gamma 1 that is clinically approved for treating Alzheimer’s disease by binding to amyloid oligomers, protofibrils, and insoluble fibrils to clear Aβ aggregates in the brain. Although therapeutically effective, Lecanemab is associated with the side effect of amyloid-related imaging abnormalities. Besides, the antibody drugs are more prone to batch-to-batch quality variations due to impurities, oxidation, modifications and other potential factors. We have therefore performed the protein content analysis, the intact protein analysis, the N-glycoproteomics analysis of Lecanemab by LC-MS/MS or LC-MS. We also used MSfragger to search potential modifications on Lecanemab. The results provide molecular bases not only useful for studying the side effect of Lecanemab, but also for monitoring quality controls among different product batches. Here we provide the MS raw data and the searching results of LC-MS/MS, LC-MS, and the N-glycoproteomics analysis of Lecanemab. |
| HostingRepository | iProX |
| AnnounceDate | 2025-07-29 |
| AnnouncementXML | Submission_2025-07-29_20:01:59.462.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Bing Bai |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive HF |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-07-29 19:43:25 | ID requested | |
| ⏵ 1 | 2025-07-29 20:01:59 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Alzheimer’s disease, Lecanemab, Mass Spectrometry, LC-MS/MS, LC-MS, proteomics, N-glycoproteomics, MSfragger |
Contact List
| Bing Bai | |
|---|---|
| contact affiliation | Nanjing University |
| contact email | bing.bai@nju.edu.cn |
| lab head | |
| Bing Bai | |
| contact affiliation | Nanjing University |
| contact email | bing.bai@nju.edu.cn |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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