⮝ Full datasets listing
PXD066730-1
PXD066730 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | SPEN is an androgen receptor dependent tumor suppressor and mediates hormonal therapy resistance in prostate cancer |
| Description | CRISPR-mediated loss of function show SPEN regulates cell cycle and other resistance associated pathways in hormone sensitive prostate cancer cells. In addition, loss of SPEN is associated with increased global protein synthesis secondary to down-regulation of the Integrated Stress Response pathway. LNCaP cells were treated with enzalutamide or DMSO for 72 hours and harvested for TMT-Mass Spectrometry analysis. |
| HostingRepository | MassIVE |
| AnnounceDate | 2026-08-06 |
| AnnouncementXML | Submission_2026-08-06_14:08:46.010.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Fred Hutch Proteomics Core |
| SpeciesList | scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Eclipse |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-07-29 11:14:35 | ID requested | |
| ⏵ 1 | 2026-08-06 14:08:46 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: Nascent mass spectrometry, Prostate cancer, DatasetType:Proteomics |
Contact List
| Andrew Hsieh | |
|---|---|
| contact affiliation | Fred Hutchinson Cancer Center |
| contact email | ahsieh@fredhhutch.org |
| lab head | |
| Fred Hutch Proteomics Core | |
| contact affiliation | Fred Hutchinson Cancer Research Center |
| contact email | pgafken@fredhutch.org |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v10/MSV000098670/ |
