PXD066693-1
PXD066693 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Proteomics of mouse bone marrow MLL-AF9 leukemia cells treated with Lep or Allo-aca in combination with Arac |
| Description | Leptin is enriched in bone marrow adipose tissue, but its impact on therapeutic response in acute myeloid leukemia (AML) remains incompletely elucidated. Here, we report that in MLL-AF9 mouse model, exogenous leptin significantly compromised the cytotoxicity of Ara-C, whereas a high-affinity leptin receptor antagonist, Allo-aca, restored chemosensitivity without altering basal leukemia growth, accompanied by marked alterations in mitochondria-associated proteins. |
| HostingRepository | iProX |
| AnnounceDate | 2025-07-28 |
| AnnouncementXML | Submission_2025-07-28_20:55:29.096.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Huifang Huang |
| SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Astral |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-07-28 20:55:11 | ID requested | |
| ⏵ 1 | 2025-07-28 20:55:29 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: AML,Lep,Allo-aca |
Contact List
| Huifang Huang | |
|---|---|
| contact affiliation | Fujian Medical University Union Hospital |
| contact email | huanghuif@fjmu.edu.cn |
| lab head | |
| Huifang Huang | |
| contact affiliation | Fujian Medical University Union Hospital |
| contact email | huanghuif@fjmu.edu.cn |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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