PXD066685 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Characterization of stromal cells isolated from endometriotic lesions |
| Description | Endometriosis shows significant lesion heterogeneity, but pathophysiological mechanisms leading to differences in clinical presentation are poorly understood. Here we utilized primary stromal cells from different types of endometriotic lesions to better understand the molecular mechanisms that lead to endometriosis heterogeneity. For this aim, endometrial stromal cells (ESCs) were obtained from eutopic endometrium (EU), endometrioma (OMA), superficial (SF) and deep (DE) endometriosis lesions and analyzed in vitro for their behavior regarding proliferation, migration, and contractility. Proteomics was used to explore the molecular mechanism underlying the observed changes. |
| HostingRepository | PRIDE |
| AnnounceDate | 2025-12-15 |
| AnnouncementXML | Submission_2025-12-14_16:43:02.498.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Marianne Spalinger |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
| Instrument | Orbitrap Exploris 480 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-07-28 17:01:05 | ID requested | |
| ⏵ 1 | 2025-12-14 16:43:03 | announced | |
Publication List
| Rodriguez Gutierrez D, Spalinger MR, Astourian A, Evrova O, Berclaz L, Hartmann M, Dedes I, Imesch P, Metzler JM, Witzel I, Shilaih M, Vongrad V, Leeners B, Endometrial Stromal Cells from Endometriosis Patients Reflect Lesion-Type-Specific Heterogeneity. Cells, 14(23):(2025) [pubmed] |
| 10.3390/cells14231891; |
Keyword List
| submitter keyword: eutopic and ectopic endometrial cells, endometriosis, endometrioma, superficial endometriosis, endometrium, endometriotic stromal cells,Homo sapiens, deep endometriosis |
Contact List
| Marianne Spalinger |
|---|
| contact affiliation | Department of Reproductive Endocrinology - University of Zurich, Switzerland |
| contact email | marianne.spalinger@usz.ch |
| lab head | |
| Marianne Spalinger |
|---|
| contact affiliation | Department for Reproductive Endocrinology, University Hospital Zürich |
| contact email | marianne.spalinger@usz.ch |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
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| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD066685
- Label: PRIDE project
- Name: Characterization of stromal cells isolated from endometriotic lesions
