PXD066683-1

PXD066683 is an original dataset announced via ProteomeXchange.

Title	New proteomic signature in circulating extracellular vesicles from tumor-draining and peripheral veins of patients with lung adenocarcinoma
Description	The identification of noninvasive prognostic biomarkers for monitoring relapse in patients with locally advanced lung cancer remains a primary objective. Tumor-draining vein (TDV) plasma samples are known to be enriched in cancer biomarkers compared to peripheral vein (PV) samples. Therefore, we aimed to investigate the proteomic profile of extracellular vesicles (EVs) from TDV and PV plasma samples in patients undergoing surgery for lung adenocarcinoma. A comparison with proteomic analyzes from tumor and non-tumor tissues was performed in parallel. Purified EVs from TDV and PV plasma samples were characterized for size distribution and concentration using nanoparticles tracking analysis. Proteomic profiling of TDV-derived and PV-derived EVs was performed using mass spectrometry (nanoLC-MS/MS) analysis, as the proteomic profile of tumor tissue and adjacent non-tumoral counterparts. Twenty patients operated for a lung adenocarcinoma were enrolled.
HostingRepository	PRIDE
AnnounceDate	2025-07-29
AnnouncementXML	Submission_2025-07-28_23:45:21.148.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Luc Negroni
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2025-07-28 13:50:50	ID requested
⏵ 1	2025-07-28 23:45:21	announced

Dataset with its publication pending

ProteomeXchange project tag: Human Proteome Project

submitter keyword: tumor-draining vein, extracellular vesicles,Lung adenocarcinoma, proteomic

Fabrice Lalloué
contact affiliation	UMR INSERM 1308 CAPTuR, Faculty of Medicine of Limoges
contact email	fabrice.lalloue@unilim.fr
lab head
Luc Negroni
contact affiliation	CNRS
contact email	luc.negroni@igbmc.fr
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/07/PXD066683

PRIDE project URI

• PRIDE
  1. PXD066683
     1. Label: PRIDE project
     2. Name: New proteomic signature in circulating extracellular vesicles from tumor-draining and peripheral veins of patients with lung adenocarcinoma