PXD066660 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Myeloid cell-mediated killing of BCP-ALL by IgA2 variants of CD38 or CD20 antibodies is enhanced by CD47/SIRPα interference |
| Description | Characterization of therapeutic monoclonal antibodies used in the context of B-cell precursor acute lymphoblastic leukemia (BCP-ALL). IgA2 antibodies targeting CD38 were analyzed using LC-MS/MS. Mass analysis, peptide mapping and glycoprofiling were performed to confirm sequence integrity and post-translational modifications. The analysis supports preclinical evaluation of antibody-based immunotherapies and provides insights into glycosylation relevant for effector function. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-06-09 |
| AnnouncementXML | Submission_2026-06-08_21:35:09.422.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Arturo Macarron Palacios |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | 6545 Q-TOF LC/MS |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-07-28 06:18:47 | ID requested | |
| ⏵ 1 | 2026-06-08 21:35:09 | announced | |
Publication List
Keyword List
| submitter keyword: peptide mapping, LC-MS, glycoprofiling,Daratumomab-IgA |
Contact List
| Arturo Macarrón Palacios |
|---|
| contact affiliation | GenCC GmbH & Co. KG, Germany |
| contact email | arturo.macarron@gencc.eu |
| lab head | |
| Arturo Macarron Palacios |
|---|
| contact affiliation | GenCC GmbH & Co. KG |
| contact email | arturo.macarron@gencc.eu |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD066660 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD066660
- Label: PRIDE project
- Name: Myeloid cell-mediated killing of BCP-ALL by IgA2 variants of CD38 or CD20 antibodies is enhanced by CD47/SIRPα interference
