PXD066557-1

PXD066557 is an original dataset announced via ProteomeXchange.

Title	vaccination protects against COVID-associated pulmonary fibrin deposition
Description	Our recent work showed COVID BALF from vaccinated individuals contained significantly lower concentration of fibrinogen and prothrombin, suggesting a potential benefit of vaccination being lower risk of fibrin clotting and acute lung injury. As our previous mass spec-based proteomic ID approach showed the presence over 500 proteins in BALF, we propose to compare the presence of various inflammatory, coagulation factors between vaccinated and unvaccinated BALF through proteomic approach. The research has potential to reveal the benefit of vaccination to prevent lung fibrosis.
HostingRepository	PRIDE
AnnounceDate	2025-10-06
AnnouncementXML	Submission_2025-10-06_06:25:57.518.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Peter Sun
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	acetylated residue; monohydroxylated residue; deamidated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2025-07-24 11:12:57	ID requested
⏵ 1	2025-10-06 06:25:57	announced

Dataset with its publication pending

submitter keyword: fibrin clotting, BAL, COVID, pulmonary disease, bronchi alveolar lavage,SARS-COVID-2

Peter D. Sun
contact affiliation	Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA
contact email	psun@nih.gov
lab head
Peter Sun
contact affiliation	NIAID,National Institutes of Health
contact email	psun@nih.gov
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/10/PXD066557

PRIDE project URI

• PRIDE
  1. PXD066557
     1. Label: PRIDE project
     2. Name: vaccination protects against COVID-associated pulmonary fibrin deposition