PXD066554 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Loss of FAM60A disrupts Sin3/HDAC control of the Hippo signaling and promotes oncogenic YAP1 activation |
| Description | FAM60A, a Sin3/HDAC subunit with defined chromatin roles, has broader functions unveiled here. Integrating immunological, biochemical, CRISPR/Cas9, genomic and proteomic analyses, we mapped the FAM60A interaction network. Proteomic profiling revealed direct binding to HDAC1 and associations with RNA and DNA binding proteins. HDAC1 knockout abolished FAM60A–SIN3A complex formation. FAM60A loss rewired transcription, downregulating WWC3 scaffold levels and triggering YAP1 dephosphorylation, nuclear accumulation, G₁ enrichment and metabolic stress resistance. Reintroducing FAM60A or WWC3 restored Hippo off signaling, normalized cell-cycle distribution and reversed stress resistance. These findings position FAM60A as an epigenetic tuner of Hippo signaling via the FAM60A–HDAC1–WWC3 axis and highlight its therapeutic potential in YAP-driven cancers. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-05-01 |
| AnnouncementXML | Submission_2026-05-01_11:16:47.504.xml |
| DigitalObjectIdentifier | https://doi.org/10.6019/PXD066554 |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Dennis Province |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | iodoacetamide derivatized residue |
| Instrument | LTQ |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-07-24 10:26:10 | ID requested | |
| ⏵ 1 | 2026-05-01 11:16:48 | announced | |
Publication List
Keyword List
| submitter keyword: Halo-Tag, LC-MS,FAM60A |
Contact List
| Sayem Miah PhD |
|---|
| contact affiliation | College of Medicine, University of Arkansas for Medical Science |
| contact email | MSMiah@uams.edu |
| lab head | |
| Dennis Province |
|---|
| contact affiliation | UAMS |
| contact email | dprovince@uams.edu |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
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| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD066554
- Label: PRIDE project
- Name: Loss of FAM60A disrupts Sin3/HDAC control of the Hippo signaling and promotes oncogenic YAP1 activation
