PXD066551 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Role of activating transcription factor 4 (ATF4) in mGluR-LTD |
| Description | Metabotropic glutamate receptor (mGluR)-dependent long-term depression (LTD) is an essential mechanism of synaptic plasticity across various brain regions and is closely linked to numerous learning processes. Previous studies have demonstrated the interplay between mGluR-LTD and the phosphorylation of eukaryotic translation initiation factor 2α (p-eIF2α), a key component of the integrated stress response (ISR) pathway. However, the role of activating transcription factor 4 (ATF4)—the primary downstream effector of the integrated stress response (ISR)—in the mechanisms underlying mGluR-LTD has not been thoroughly investigated. In this study, we examine the role of ATF4 in mGluR-LTD and identify several targets that show differential expression when the gene encoding ATF4 is deleted in excitatory neurons. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-02-05 |
| AnnouncementXML | Submission_2026-02-04_23:19:35.530.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Niaz Mahmood |
| SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090; |
| ModificationList | amidated residue; monohydroxylated residue; iodoacetic acid derivatized residue |
| Instrument | Orbitrap Fusion |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-07-24 09:45:39 | ID requested | |
| ⏵ 1 | 2026-02-04 23:19:36 | announced | |
Publication List
| Dataset with its publication pending |
Keyword List
Contact List
| Nahum Sonenberg |
|---|
| contact affiliation | Department of Biochemistry, McGill University, Montreal, Canada |
| contact email | nahum.sonenberg@mcgill.ca |
| lab head | |
| Niaz Mahmood |
|---|
| contact affiliation | McGill University |
| contact email | niaz.mahmood@mail.mcgill.ca |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/02/PXD066551 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD066551
- Label: PRIDE project
- Name: Role of activating transcription factor 4 (ATF4) in mGluR-LTD
