PXD066546 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Beyond Traditional SPAAC: Achieving Orthogonality and Rapid Kinetics with Fluoroalkyl Azides |
| Description | Selective modification of biological systems via click reactions is an important method to study their properties and function under native conditions. One of the most used method is the strain-promoted azide-alkyne cycloaddition (SPAAC) reaction between azides and strained cyclooctynes. In this work, we show, that fluorination of the azide reagents enhances their click reactivity and enables achieving of excellent selectivity when used in combination with simple alkyl azides. This work extends the available toolkit for efficient and selective modification of (bio)molecules under benign, metal-free condition. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-05-25 |
| AnnouncementXML | Submission_2026-05-24_16:12:50.748.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Frantisek Filandr |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Synapt MS |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-07-24 09:02:52 | ID requested | |
| ⏵ 1 | 2026-05-24 16:12:51 | announced | |
Publication List
| Tom, č, o M, Š, lachtov, á V, Vr, á, bel M, Li J, Filgas J, Slav, í, č, ek P, Bedn, á, rov, á L, Filandr F, Beier P, Beyond traditional strain-promoted azide-alkyne cycloadditions by achieving orthogonality and rapid kinetics with fluoroalkyl azides. Commun Chem, 9(1):(2026) [pubmed] |
| 10.1038/s42004-026-01927-6; |
Keyword List
| submitter keyword: LC-MS, PTM, Top-Down, mAb |
Contact List
| Milan Vrábel |
|---|
| contact affiliation | Institute of Organic Chemistry and Biochemistry of the CAS |
| contact email | milan.vrabel@uochb.cas.cz |
| lab head | |
| Frantisek Filandr |
|---|
| contact affiliation | Institute of Organic Chemistry and Biochemistry of the CAS |
| contact email | filandr.frantisek@gmail.com |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD066546 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD066546
- Label: PRIDE project
- Name: Beyond Traditional SPAAC: Achieving Orthogonality and Rapid Kinetics with Fluoroalkyl Azides
