PXD066511 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Proteomic analysis of the thryoid eye disease tear film |
| Description | Thyroid eye disease (TED) is a complex autoimmune disease that is often disfiguring and sight threatening. Recent advances have shifted the treatment paradigm from traditional immunosuppressive therapies such as corticosteroids to targeted biologic agents, such as teprotumumab (TMB; anti-IGF-1R) which has been demonstrated to improve proptosis, diplopia, and inflammatory signs in TED patients. In patients with limited response to teprotumumab, developing new drug targets or repositioning already-approved drugs can bring effective, alternative options. To identify new drug targets for TED, we quantified protein expression in living patients using a non-invasive testing method. Tear fluid samples were collected using Schirmer strips from two groups: control patients without ocular surface disease (n = 30) and TED patients before and after treatment with TMB (n = 22). Proteins were extracted from Schirmer strips and underwent proteomic analysis. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-06-08 |
| AnnouncementXML | Submission_2026-06-08_11:40:12.689.xml |
| DigitalObjectIdentifier | https://doi.org/10.6019/PXD066511 |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Gabriel Velez |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive HF |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-07-24 00:56:14 | ID requested | |
| ⏵ 1 | 2026-06-08 11:40:13 | announced | |
Publication List
Keyword List
| submitter keyword: Thyroid eye disease, Teprotumumab, tears, TED |
Contact List
| Vinit Mahajan |
|---|
| contact affiliation | Byers Eye Institute, Stanford University |
| contact email | vinit.mahajan@stanford.edu |
| lab head | |
| Gabriel Velez |
|---|
| contact affiliation | Byers Eye Institute, Stanford Univeristy |
| contact email | gvelz@stanford.edu |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD066511 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD066511
- Label: PRIDE project
- Name: Proteomic analysis of the thryoid eye disease tear film
