PXD066505-1

PXD066505 is an original dataset announced via ProteomeXchange.

Title	Serum N-Glycoproteome Mapping Reveals Glycosite and Glycan Signatures in Type 2 Diabetes Mellitus Complicated with Coronary Heart Disease
Description	This study investigated the glycoproteomic alterations associated with the development of CHD in patients with T2DM, with a particular focus on dual-layer changes in N-glycosylation sites (N-glycosites) and intact N-glycopeptides. Serum samples were analyzed using a hydrophilic interaction liquid chromatography (HILIC)-based MS method to perform comprehensive glycoproteomic profiling at both the site-specific glycopeptide and intact N-glycopeptide levels. This approach enabled the simultaneous identification of glycosylation sites and their attached glycan structures, offering high-resolution insights into glycan heterogeneity across glycoproteins. These findings advance our understanding of the molecular mechanisms underlying T2DM&CHD and show the promising value of glycoproteomics for identifying disease-specific biomarkers.
HostingRepository	iProX
AnnounceDate	2025-07-24
AnnouncementXML	Submission_2026-03-02_01:24:20.563.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jueping Chen
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2025-07-23 21:42:23	ID requested
⏵ 1	2026-03-02 01:24:21	announced

Dataset with its publication pending

submitter keyword: Human serum, glycoproteomics, N-glycopeptide, N-glycosite

Dapeng Li
contact affiliation	Sichuan University
contact email	dpli@scu.edu.cn
lab head
Jueping Chen
contact affiliation	Sichuan University
contact email	18258908007@163.com
dataset submitter

iProX dataset URI