PXD066355 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Proteomic Profiling of Mycobacterium tuberculosis in Response to ILE Treatment |
| Description | This study aims to elucidate the global proteomic changes in Mycobacterium tuberculosis upon treatment with the novel compound ilamycin E(ILE), which targets the Clp protease system. Label-free quantitative proteomics was employed to assess differential protein expression after ILE exposure. The results reveal that ILE induces significant alterations in the expression of proteins involved in proteolysis, stress response, redox homeostasis, and energy metabolism, providing valuable insights into the adaptive response and potential mechanism of action of ILE in M. tuberculosis. These data support further development of ILE as a candidate anti-mycobacterial agent targeting intracellular proteostasis. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-02-09 |
| AnnouncementXML | Submission_2026-02-08_16:34:40.079.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Cuiting Fang |
| SpeciesList | scientific name: Mycobacterium tuberculosis H37Ra; NCBI TaxID: NEWT:419947; |
| ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
| Instrument | Q Exactive HF |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-07-21 02:13:18 | ID requested | |
| ⏵ 1 | 2026-02-08 16:34:41 | announced | |
Publication List
| 10.1038/s42003-025-08646-z; |
| Gao Y, Fang C, Zhou B, Hameed HMA, Sun C, Tian X, He J, Han X, Zhang H, Li J, Ju J, Chen X, Zhong N, Ma J, Xiong X, Zhang T, Mutations in ClpC1 or ClpX subunit of caseinolytic protease confer resistance to ilamycins in mycobacteria. Commun Biol, 8(1):1219(2025) [pubmed] |
Keyword List
| submitter keyword: Mycobacterium tuberculosis, tuberculosis, ilamycin E |
Contact List
| Tianyu Zhang |
|---|
| contact affiliation | State Key Laboratory of Respiratory Disease, Institute of Drug Discovery, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences |
| contact email | zhang_tianyu@gibh.ac.cn |
| lab head | |
| Cuiting Fang |
|---|
| contact affiliation | Guangzhou Chest Hospital |
| contact email | fangcty@126.com |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/02/PXD066355 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD066355
- Label: PRIDE project
- Name: Proteomic Profiling of Mycobacterium tuberculosis in Response to ILE Treatment
