PXD066352-1
PXD066352 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Antler Proteome Atlas for endochondral ossification |
| Description | Antler primary growth center is located in the distal tip of growing antler with five consecutive tissue layers under the velvet skin. Because of blastema progenitor cells of outmost reserve mesenchymal layer with multipotent differentiation capacity, antler regeneration recapitulates embryonic skeletal development through endochondral os-sification process. To further decipher this modified endochondral ossification, we profile deer antler proteome atlas with 8000 proteins, covering the whole five layers that comprehensively represent the mesenchymal condensation, rapid mesenchymal proliferation, chondrocyte hypertrophy, cartilage mineralization. By integrating three clustering methods including WGCNA, Fuzzy C-means clustering, and Monotonic feature selector, we elucidate proteome dynamics within the growth center, identifying key factors and elucidating biological processes through GO enrichment analysis. Through comparative analysis of RNA-seq and Proteomic studies, our results reveal that mRNA exhibits greater fluctuations during the endochondral ossification process. This research offers a valuable model for investigating hub genes and their biological function involved in organ regeneration. |
| HostingRepository | iProX |
| AnnounceDate | 2025-07-21 |
| AnnouncementXML | Submission_2025-07-21_01:37:16.159.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Hang Su |
| SpeciesList | scientific name: Cervus nippon mantchuricus; NCBI TaxID: 1143719; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Astral |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-07-21 01:36:51 | ID requested | |
| ⏵ 1 | 2025-07-21 01:37:16 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Antler,Regeneration,Proteomics |
Contact List
| Xiangyan Li | |
|---|---|
| contact affiliation | Changchun University of Chinese Medicine |
| contact email | xiangyan_li1981@163.com |
| lab head | |
| Hang Su | |
| contact affiliation | Changchun University of Chinese Medicine |
| contact email | suhang0720@live.cn |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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