PXD066265 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Extracellular Exosomes Link Hypertension and Alzheimer’s Disease |
| Description | Untreated hypertension is a risk factor for late-onset Alzheimer’s disease (AD); however, this association is not well understood. The aim of this study was to reveal protein signatures that bridge the pathophysiological changes in hypertension to AD. Using untargeted proteomics, we analyzed frontal cortex brain samples from aged (30- and 40-week-old) spontaneously hypertensive rats (SHRs, n = 12), and age-matched normotensive Wistar Kyoto (WKY, n = 8) controls, and human AD patients (Braak stages 4-6) (n = 30), cerebral amyloid angiopathy (CAA) (n = 5), non-demented controls (Braak stages 0-3) (n = 37). Following differential expression analyses in each species, we identified 24 proteins in SHRs and AD, whose trajectory pattern over the progression of hypertension, aligned with those observed during AD Braak stage progression, compared to respective controls. The proteins were significantly associated with extracellular exosomes. Immunostaining and spatial proteomics support vesicle accumulation and dysregulated exosome protein signatures in the cerebrovasculature of both SHR and AD brains. Our findings demonstrate cross-species translatability between AD and the SHR and provide novel mechanistic insights into a shared dysregulation of cerebral artery-associated exosomes. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-02-13 |
| AnnouncementXML | Submission_2026-02-13_03:49:17.589.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Joakim Bastrup |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | timsTOF Pro |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-07-17 09:45:01 | ID requested | |
| ⏵ 1 | 2026-02-13 03:49:18 | announced | |
Publication List
Keyword List
| submitter keyword: Hypertension, Alzheimer’s disease, exosomes, proteomics |
Contact List
| Thomas A. Jepps |
|---|
| contact affiliation | Department of Biomedical Sciences, Jepps group, University of Copenhagen, Denmark (lab head) |
| contact email | tjepps@sund.ku.dk |
| lab head | |
| Joakim Bastrup |
|---|
| contact affiliation | Department of Biomedical Sciences, University of Copenhagen, Denmark |
| contact email | joakimbastrup@hotmail.dk |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/02/PXD066265 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD066265
- Label: PRIDE project
- Name: Extracellular Exosomes Link Hypertension and Alzheimer’s Disease
