PXD066197-1

PXD066197 is an original dataset announced via ProteomeXchange.

Title	Multi-omics Analysis Reveals Age- Associated Molecular Mechanisms in SARS-CoV-2 and Influenza Virus Infection
Description	To elucidate the clinical manifestations of SARS-CoV-2 and influenza virus infection across different age groups, C57BL/6N mice (n = 3/group) were inoculated with 4×104 tissue culture infective dose (TCID50) of SARS-CoV-2 Beta variant (B.1.351) and influenza virus through the intranasal route. The blank untreated control groups of the young group (pyp), adult-aged group (pmp) and elderly group (pop) received an equal amount of sterile phosphate-buffered saline (PBS) through the nasal route. Four days following infection, the animals were euthanized and their lung tissues were harvested for the purposose of phosphoproteomics and proteomics analysis analyses
HostingRepository	iProX
AnnounceDate	2025-07-16
AnnouncementXML	Submission_2026-02-01_21:59:26.870.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Xiaoyue Tang
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	phosphorylated residue
Instrument	Orbitrap Exploris 240

Revision	Datetime	Status	ChangeLog Entry
0	2025-07-16 01:26:57	ID requested
⏵ 1	2026-02-01 21:59:27	announced

Dataset with its publication pending

submitter keyword: SARS-CoV-2,influenza virus, aging, multi-omics, inflammatory responses, kinase

Juntao Yang
contact affiliation	Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College
contact email	superyjt79@163.com
lab head
Xiaoyue Tang
contact affiliation	School of Basic Sciences, Peking Union Medical College
contact email	b2023005043@pumc.edu.cn
dataset submitter

iProX dataset URI