PXD066170 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Integrative Proteomic and Bioenergetic Profiling Reveals Diet- and Strain-Specific Mitochondrial Dysfunction in Cohen Diabetic Rat Hearts |
| Description | Cytochrome-c oxidase (CcO) is the terminal enzyme of the electron transport chain, where it catalyzes the reduction of oxygen to water. The oxygen-binding site is located near subunit I (CcO1), which is subject to tight regulatory control, including phosphorylation. Under diabetic conditions associated with inflammation, we observed increased phosphorylation at tyrosine 304 (Y304) of CcO1. This modification occurs specifically in dimeric CcO and certain respiratory supercomplexes, leading to reduced enzymatic activity. Our findings indicate that pY304 plays a key role in the diet- and strain-dependent regulation of mitochondrial function in diabetic heart tissue. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-08-17 |
| AnnouncementXML | Submission_2026-08-16_16:17:18.142.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Tasnim Arroum |
| SpeciesList | scientific name: Rattus norvegicus (Rat); NCBI TaxID: NEWT:10116; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Eclipse |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-07-15 07:26:23 | ID requested | |
| ⏵ 1 | 2026-08-16 16:17:18 | announced | |
Publication List
| 10.3390/antiox15020248; |
| Pavelich L, Arroum T, Pham L, Komnenov D, Stemmer PM, Lax R, Saada A, Weksler-Zangen S, H, ü, ttemann M, Integrative Proteomic and Bioenergetic Profiling Reveals Diet- and Strain-Specific Mitochondrial Dysfunction in Cohen Diabetic Rat Hearts. Antioxidants (Basel), 15(2):(2026) [pubmed] |
Keyword List
Contact List
| Maik Hüttemann |
|---|
| contact affiliation | Wayne State University, Molecular Medicine and Genetics and of Biochemistry, Microbiology, and Immunology, USA |
| contact email | mhuttema@med.wayne.edu |
| lab head | |
| Tasnim Arroum |
|---|
| contact affiliation | Wayne State University |
| contact email | ho0066@wayne.edu |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/08/PXD066170 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD066170
- Label: PRIDE project
- Name: Integrative Proteomic and Bioenergetic Profiling Reveals Diet- and Strain-Specific Mitochondrial Dysfunction in Cohen Diabetic Rat Hearts
