PXD066155-1

PXD066155 is an original dataset announced via ProteomeXchange.

Title	Mammalian H4K16ac regulates the spatiotemporal order of genome replication rather than gene expression
Description	Histone acetylation is widely assumed to directly instruct gene activation. Among acetylated residues, H4K16ac is one of the most abundant modifications, conserved across all eukaryotes. Here we analyzed histone PTM profiles in MSL KO and HDAC inhibitor-treated cells.
HostingRepository	PRIDE
AnnounceDate	2025-09-29
AnnouncementXML	Submission_2025-09-28_16:14:07.910.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Roberta Noberini
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monomethylated residue; N6; acetylated residue; N6
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2025-07-15 02:03:31	ID requested
⏵ 1	2025-09-28 16:14:08	announced

Milan M, Runfola V, Patel M, Falbo L, Noberini R, Soriani C, Rodighiero S, Bonaldi T, Costanzo V, Pradeepa MM, Scaffidi P, Mammalian H4K16ac regulates the spatiotemporal order of genome replication rather than gene expression. Nucleic Acids Res, 53(18):(2025) [pubmed]

10.1093/nar/gkaf916;

submitter keyword: Histone post translationa modification, H4K16ac

Tiziana Bonaldi
contact affiliation	European Institute of Oncology, Milan, Italy
contact email	tiziana.bonaldi@ieo.it
lab head
Roberta Noberini
contact affiliation	Istituto Europeo di Oncologia
contact email	roberta.noberini@ieo.it
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/09/PXD066155

PRIDE project URI

• PRIDE
  1. PXD066155
     1. Label: PRIDE project
     2. Name: Mammalian H4K16ac regulates the spatiotemporal order of genome replication rather than gene expression