PXD066146-1

PXD066146 is an original dataset announced via ProteomeXchange.

Title	Protoemics of nasal and bronchial mucus from primary human airway epithelial cells grown at air-liquid interface.
Description	Differentiated primary human respiratory epithelial cells grown at air-liquid interface have become a widely used cell culture model of the human conducting airways. These cultures contain secretory cells such as goblet and club cells, which produce and secrete mucus. Here, we characterize the composition of mucus harvested from airway cultures of nasal and bronchial origin. We find that despite inter-donor variability, the protein content and composition is very similar between nasal and bronchial mucus. However, subtle differences in the abundance of individual components in nasal versus bronchial mucus can influence its antimicrobial properties.
HostingRepository	PRIDE
AnnounceDate	2025-08-13
AnnouncementXML	Submission_2025-08-13_01:02:42.010.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Marie Pohl
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2025-07-15 01:06:21	ID requested
⏵ 1	2025-08-13 01:02:42	announced

10.1128/MSPHERE.00365-25;

submitter keyword: LC-MSMS, human airway epithelial cells,Mucus

Silke Stertz
contact affiliation	Institute of Medical Virology, University of Zurich, Zurich, Switerland
contact email	stertz.silke@virology.uzh.ch
lab head
Marie Pohl
contact affiliation	University of Zurich
contact email	pohl.marie@virology.uzh.ch
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/08/PXD066146

PRIDE project URI

• PRIDE
  1. PXD066146
     1. Label: PRIDE project
     2. Name: Protoemics of nasal and bronchial mucus from primary human airway epithelial cells grown at air-liquid interface.