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PXD066144-1

PXD066144 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleLysosome-targeting chimeras based on retinoic acid modification for cancer therapy
DescriptionWe developed retinoic acid-based LYTACs (RATACs) to overcome synthesis and druggability issues. RATACs degrade EGFR, PD-L1, TGF-β, and IgG, showing superior anti-tumor effects in liver and lung cancer models compared to conventional antibodies.
HostingRepositoryiProX
AnnounceDate2025-07-14
AnnouncementXMLSubmission_2025-07-15_01:04:45.833.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterYuting Lu
SpeciesList scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumenttimsTOF Pro
Dataset History
RevisionDatetimeStatusChangeLog Entry
02025-07-15 01:04:31ID requested
⏵ 12025-07-15 01:04:46announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: LYTAC, RA, cancer therapy
Contact List
Longguang Tang
contact affiliationZhejiang University
contact emailtanglongguang@zju.edu.cn
lab head
Yuting Lu
contact affiliationZhejiang University
contact email22218193@zju.edu.cn
dataset submitter
Full Dataset Link List
iProX dataset URI

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