PXD066110-1

PXD066110 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	PROTAC repurposing uncovers a noncanonical binding surface that mediates chemical degradation of nuclear receptors
Description	MD-224 is a PROTAC that induces degradation of the human protein MDM2. However, we have found that it also induces degradation of a subset of nuclear receptors. DIA was performed to assess the overall specificity of MD-224 in 293T cells and the colorectal cancer cell line SNU-C4.
HostingRepository	PRIDE
AnnounceDate	2025-09-18
AnnouncementXML	Submission_2025-09-18_08:53:18.644.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Zuo-Fei Yuan
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF HT

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2025-07-14 13:35:20	ID requested
⏵ 1	2025-09-18 08:53:19	announced

Publication List

Dataset with its publication pending

Dataset with its publication pending

Keyword List

submitter keyword: DIA proteomics, PXR, PROTAC, MDM2, nuclear receptor, MD-224

submitter keyword: DIA proteomics, PXR, PROTAC, MDM2, nuclear receptor, MD-224

Contact List

Anthony A High
contact affiliation	Center for Proteomics & Metabolomics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA
contact email	anthony.high@stjude.org
lab head
Zuo-Fei Yuan
contact affiliation	St. Jude Children's Research Hospital
contact email	zuo-fei.yuan@stjude.org
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/09/PXD066110
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/09/PXD066110

PRIDE project URI

Repository Record List

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