PXD066108 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | A proteomics data of 30 tissues in aging female rhesus macaques (Macaca mulatta) |
| Description | A systematic investigation of aging patterns across virtually all major tissues in non-human primates, our evolutionarily closest relatives, can provide valuable insights into tissue aging in humans, which is still elusive largely due to the difficulty in sampling. Here, we generated and analyzed multi-omics data, including transcriptome, proteome, and metabolome, from 30 tissues of 17 female rhesus macaques (Macaca mulatta) aged 3 to 27 years. We found that certain molecular features, such as increased inflammation, are consistent across tissues and align with findings in mice and humans. We further revealed that tissue aging in macaques is asynchronous and can be classified into two distinct types, with one type exhibiting more pronounced aging degree, likely associated with decreased mRNA translation efficiency, and predominantly contributing to whole-body aging. This work provides a comprehensive molecular landscape of aging in non-human primate tissues and links translation efficiency to tissue-specific aging. |
| HostingRepository | PRIDE |
| AnnounceDate | 2025-11-06 |
| AnnouncementXML | Submission_2025-11-05_19:19:54.799.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Gong-Hua Li |
| SpeciesList | scientific name: Macaca mulatta (Rhesus macaque); NCBI TaxID: NEWT:9544; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive HF |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-07-14 13:24:40 | ID requested | |
| ⏵ 1 | 2025-11-05 19:19:55 | announced | |
Publication List
Keyword List
| submitter keyword: Proteomics |
| Tissue aging |
| Rhesus macaques |
| LC-MS |
| DIA |
Contact List
| Qing-Peng Kong |
|---|
| contact affiliation | State Key Laboratory of Genetic Evolution & Animal Models,Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650201, China. |
| contact email | kongqp@mail.kiz.ac.cn |
| lab head | |
| Gong-Hua Li |
|---|
| contact affiliation | Kunming Institute of Zoology, Chinese Academy of Sciences |
| contact email | ligonghua@mail.kiz.ac.cn |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
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| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD066108
- Label: PRIDE project
- Name: A proteomics data of 30 tissues in aging female rhesus macaques (Macaca mulatta)
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