PXD066087-1

PXD066087 is an original dataset announced via ProteomeXchange.

Title	Early retinal synaptic dysfunction and proteomic remodeling precede neurodegeneration in a Parkinson’s disease model
Description	Parkinson’s disease (PD) affects motor and non-motor systems, but retinal changes and their molecular basis are not well understood. Using a transgenic mouse model overexpressing A53T-mutant human α-synuclein, we examined retinal function, structure, and proteomics at 6 and 16 months. Early retinal dysfunction was detected by reduced ERG b-wave amplitudes and oscillatory potentials, preceding photoreceptor loss. OCT showed thinning of ganglion cell and photoreceptor layers with thickening of the inner plexiform layer. Phosphorylated α-synuclein and increased GFAP indicated early neuroinflammation. Proteomic profiling revealed stage-dependent alterations involving α-synuclein, oxidative stress markers, and crystallins. Network analysis showed a progression from α-synuclein-related changes to immune-metabolic remodeling. These results highlight retinal alterations as early indicators of PD neurodegeneration, offering new insights into disease mechanisms.
HostingRepository	PRIDE
AnnounceDate	2026-02-23
AnnouncementXML	Submission_2026-02-22_16:39:37.514.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Chae Eun Moon
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue; acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2025-07-13 09:41:36	ID requested
⏵ 1	2026-02-22 16:39:38	announced

10.1038/s41531-026-01261-7;

Moon CE, Lee SJ, Shin H, Kim H, Lee JK, Kim H, Kang H, Moon IH, Kim SS, Lee HK, Seo KY, Cho SR, Ji YW, Early retinal synaptic dysfunction and proteomic remodeling precede neurodegeneration in a Parkinson's disease model. NPJ Parkinsons Dis, 12(1):47(2026) [pubmed]

submitter keyword: Visual dysfunction, Retina,Parkinson's disease, Proteomics

Yong Woo
contact affiliation	Department of Ophthalmology, Yongin Severance Hospital, Yonsei University College of Medicine, Republic of Korea
contact email	LUSITA30@yuhs.ac
lab head
Chae Eun Moon
contact affiliation	Yonsei University College of Medicine
contact email	cemoon@yuhs.ac
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/02/PXD066087

PRIDE project URI

• PRIDE
  1. PXD066087
     1. Label: PRIDE project
     2. Name: Early retinal synaptic dysfunction and proteomic remodeling precede neurodegeneration in a Parkinson’s disease model