⮝ Full datasets listing
PXD066056-1
PXD066056 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Loss of ADAM15 prevents necroptosis induction by partial RIPK1 degradation and altered organelle organization. |
| Description | Death receptor-mediated signaling pathways must be tightly regulated to ensure tissue homeostasis. In a previous study, ADAM15 was identified as a possible TNF-regulated protease. We here unveil ADAM15 as a regulator of TNF-mediated necroptosis, while apoptosis and survival pathways remain unaffected. ADAM15 knockout results in the modulation of death-associated proteins and protein networks. Using a bottom-up proteomics screen to compare human U937 wild-type and ADAM15 knockdown cells enabled us to identify proteins and networks affected by ADAM15 loss, and which may be involved in necroptosis regulation. |
| HostingRepository | jPOST |
| AnnounceDate | 2026-07-11 |
| AnnouncementXML | Submission_2026-07-10_08:00:04.857.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Tanja Ziesmann |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
| ModificationList | S-carboxamidomethyl-L-cysteine; alpha-amino acetylated residue; L-methionine sulfoxide |
| Instrument | Orbitrap Exploris 480 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-07-11 06:50:36 | ID requested | |
| ⏵ 1 | 2026-07-10 08:00:05 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: ADAM15, death receptor signaling, cell death, necroptosis, apoptosis |
Contact List
| Jürgen Fritsch | |
|---|---|
| lab head | |
| Tanja Ziesmann | |
| contact affiliation | Insitute of Immunology, University Medical Center Mainz |
| dataset submitter | |
Full Dataset Link List
| jPOST dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.jpostdb.org/JPST003922/ |
