PXD066039-1

PXD066039 is an original dataset announced via ProteomeXchange.

Title	Identification of Khib substrates of histone regulated by NAT10
Description	Having established NAT10’s regulatory role in lysine 2-hydroxyisobutyrylation, we aimed to identify the histone Khib sites targetedby NAT10. To this end, we extracted and digested core histones from cells with or without NAT10 depletion, followed by chemical derivatization of amine groups. The resulting peptides were analyzed by data-independent acquisition (DIA) mass spectrometry to detect the NAT10-modulated Khib sites.
HostingRepository	PRIDE
AnnounceDate	2026-01-27
AnnouncementXML	Submission_2026-01-26_19:44:44.148.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	siyu wang
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	L-lysine amide
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2025-07-10 20:32:09	ID requested
⏵ 1	2026-01-26 19:44:44	announced

Dataset with its publication pending

submitter keyword: Human Liver cancer histone HPLC-MS/MS

Kai Zhang
contact affiliation	Tianjin Medical University, No. 22 Qixiangtai Road, Heping District, Tianjin
contact email	kzhang@tmu.edu.cn
lab head
siyu wang
contact affiliation	TianJin Medical University
contact email	13753216903@163.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/01/PXD066039

PRIDE project URI

• PRIDE
  1. PXD066039
     1. Label: PRIDE project
     2. Name: Identification of Khib substrates of histone regulated by NAT10