PXD065965-1

PXD065965 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Extracellular Domain Shedding of TROP2 Activates EGFR Signaling to Drive Prostate Cancer Metastasis
Description	Pull-down experiments were performed to characterize the interactome of the shed extracellular domain of TROP2 (TECD) in prostate cancer. Two independent strategies were used: (1) immunoprecipitation of TROP2 from patient sera, and (2) immunoprecipitation of DU145 cell lines treated with TECD. Proteins were analyzed by shotgun proteomics.
HostingRepository	PRIDE
AnnounceDate	2025-08-08
AnnouncementXML	Submission_2025-08-08_00:33:32.894.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Sharon Pitteri
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Eclipse

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2025-07-09 13:06:29	ID requested
⏵ 1	2025-08-08 00:33:33	announced

Publication List

Dataset with its publication pending

Dataset with its publication pending

Keyword List

submitter keyword: TROP2
TECD
Prostate Cancer
EGFR
Metastasis

submitter keyword: TROP2

TECD

Prostate Cancer

EGFR

Metastasis

Contact List

Sharon Pitteri
contact affiliation	Department of Radiology Canary Center at Stanford for Cancer Early Detection Stanford School of Medicine Stanford University
contact email	spitteri@stanford.edu
lab head
Sharon Pitteri
contact affiliation	Stanford University
contact email	spitteri@stanford.edu
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/08/PXD065965
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/08/PXD065965

PRIDE project URI

Repository Record List

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