PXD065952 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Mkrn3 binds Gnrh1 mRNA to alter subcellular localization of the Gnrh1 precursor protein - Mkrn3-AP-MS |
| Description | Loss-of-function mutations in MKRN3 cause central precocious puberty, and our findings show that MKRN3 regulates GnRH production by binding the Gnrh1 3′UTR and altering subcellular localization of its precursor protein through post-transcriptional mechanisms. This function likely involves interactions with RNA-binding proteins such as IGF2BP2 and may extend to other cell types and neuropeptides. This is work is for the affinity purification mass spectrometry (AP-MS)of MKRN3 |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-05-14 |
| AnnouncementXML | Submission_2026-05-14_05:52:15.969.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Oded Kleifeld |
| SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090; |
| ModificationList | ubiquitination signature dipeptidyl lysine; acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
| Instrument | Q Exactive Plus |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-07-09 08:38:10 | ID requested | |
| ⏵ 1 | 2026-05-14 05:52:16 | announced | |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: AP-MS,Mkrn3, Gnrh1 precursor protein |
Contact List
| Philippa Melamed |
|---|
| contact affiliation | The Dr. Irving and Jeanette Benveniste Chair in Life Sciences, Faculty of Biology, Technion-Israel Institute of Technology, Haifa 32000 ISRAEL |
| contact email | philippa@technion.ac.il |
| lab head | |
| Oded Kleifeld |
|---|
| contact affiliation | Technion |
| contact email | okleifeld@technion.ac.il |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
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| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD065952
- Label: PRIDE project
- Name: Mkrn3 binds Gnrh1 mRNA to alter subcellular localization of the Gnrh1 precursor protein - Mkrn3-AP-MS
