⮝ Full datasets listing
PXD065933-1
PXD065933 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Clinical MAPPs: a personalized healthcare-driven assay for the direct identification of potential T cell epitopes in patients |
| Description | The development of anti-drug antibodies (ADAs) in response to therapeutic monoclonal antibody (mAb) treatments can undermine their efficacy and safety. A key player in this immunogenicity is the presentation of mAb-derived peptides by dendritic cells, which activates CD4 T-helper cells. Traditionally, the MHC class II-associated peptide proteomics (MAPPs) assay is used preclinically to identify these peptides presented by monocyte-derived dendritic cells (moDCs). Here, we are introducing "clinical MAPPs?, an optimized, miniaturized version of the assay tailored for clinical use. Designed to work with cryopreserved peripheral blood mononuclear cells from low blood volumes (10 mL), clinical MAPPs offers a groundbreaking approach. Our proof-of-concept on patient material shows that clinical MAPPs enables personalized characterization of MHC-II receptor-associated antibody-derived peptides before mAb treatment. This innovative assay promises to be a critical tool for clinical immunogenicity risk assessments, enhancing personalized healthcare and ensuring safer, more effective treatments. |
| HostingRepository | MassIVE |
| AnnounceDate | 2026-06-15 |
| AnnouncementXML | Submission_2026-06-15_01:09:59.450.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Axel Ducret |
| SpeciesList | scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606; |
| ModificationList | L-methionine sulfoxide; Deamidated; Gln->pyro-Glu |
| Instrument | Q Exactive HF-X; timsTOF Pro 2 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-07-09 00:50:12 | ID requested | |
| ⏵ 1 | 2026-06-15 01:09:59 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: MAPPs assays, anti-drug antibodies, dendritic cells, immunogenicity, personalized healthcare, T cell epitope, DatasetType:Proteomics |
Contact List
| Axel Ducret | |
|---|---|
| contact affiliation | Roche Innovation Center Basel |
| contact email | axel.ducret@roche.com |
| lab head | |
| Axel Ducret | |
| contact affiliation | F. Hoffmann-La Roche Ltd |
| contact email | axel.ducret@roche.com |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v10/MSV000098460/ |
