PXD065759 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Analysis of Phosphoproteome in MAST1 Mouse Mutants |
| Description | The MAST family of serine/threonine kinases has been implicated in a spectrum of human neurodevelopmental disorders, however, little is known about their biological function, regulation or targets. Mutations in MAST1 are associated with Mega-Corpus-Callosum Syndrome with Cerebellar Hypoplasia and Cortical Malformations (MCC-CH-CM), which is characterized by enlargement of the corpus callosum, epilepsy, and severe cognitive and motor impairment. We have undertaken whole brain phosphoproteomics on two unique mouse models (L278del, G510S) that recapitulate muliple aspects of this disease at P0. We identify peptides that are differentially phosphorylated in these mice. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-09-04 |
| AnnouncementXML | Submission_2026-09-04_01:47:20.657.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Richard Imre |
| SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090; |
| ModificationList | carbamoylated residue; phosphorylated residue; monohydroxylated residue; deamidated residue; iodoacetamide derivatized residue |
| Instrument | Q Exactive HF-X |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-07-03 11:50:06 | ID requested | |
| ⏵ 1 | 2026-09-04 01:47:21 | announced | |
Publication List
Keyword List
| submitter keyword: enlarged corpus callosum,Developing brain, kinase, microtubules |
Contact List
| David Keays |
|---|
| contact affiliation | Ludwig-Maximilians-Universität-München Großhaderner Straße 2 D-82152 Planegg-Martinsried |
| contact email | Keays@bio.lmu.de |
| lab head | |
| Richard Imre |
|---|
| contact affiliation | IMBA Vienna |
| contact email | richard.imre@imba.oeaw.ac.at |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/09/PXD065759 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD065759
- Label: PRIDE project
- Name: Analysis of Phosphoproteome in MAST1 Mouse Mutants
