PXD065502-1

PXD065502 is an original dataset announced via ProteomeXchange.

Title	Affinity AP2 Proteomics Fragile X
Description	Fragile X syndrome (FXS), the most common inherited intellectual disability and monogenic cause of autism, results from loss of FMRP, which regulates mRNA translation essential for brain development and synaptic plasticity. FMRP has been implicated in the synaptic localization and surface expression of various membrane proteins, yet underlying mechanisms remain unclear. Here, we identified a broad dysregulation of membrane surface and associated proteins in FMRP-deficient neurons by quantitative mass spectrometry. Among them, we found increased steady-state levels of several subunits of the clathrin-adaptor protein complex 2 (AP-2), including AP2A1 and AP2B1.
HostingRepository	PRIDE
AnnounceDate	2025-07-09
AnnouncementXML	Submission_2025-07-09_06:17:09.277.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Duc Duong
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2025-06-26 04:53:09	ID requested
⏵ 1	2025-07-09 06:17:09	announced

10.1016/J.ISCI.2025.113062;

submitter keyword: proteomics,AP2

Gary Bassell
contact affiliation	Department of Cell Biology
contact email	gary.bassell@emory.edu
lab head
Duc Duong
contact affiliation	Center of Neurodegenerative Diseases
contact email	dduong@emory.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/07/PXD065502

PRIDE project URI

• PRIDE
  1. PXD065502
     1. Label: PRIDE project
     2. Name: Affinity AP2 Proteomics Fragile X