PXD065500-1

PXD065500 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Proteomic profiling of extracellular vesicles from Nodal KO and control mouse placentas
Description	This study evaluates the potential of placental extracellular vesicles (EVs) as biomarkers of midgestational pregnancy complications using a mouse model. EVs were isolated from embryonic day 10.5 (E10.5) placentas of control and uterine-specific Nodal knockout mice. Proteomic analyses revealed dysregulated molecules related to placental development, angiogenesis, and immune modulation. Several identified EV cargo components have known associations with complications such as IUGR and preeclampsia. These results suggest that placental EVs can reflect impaired placentation and may support early, non-invasive diagnostic strategies for reproductive disorders.
HostingRepository	PRIDE
AnnounceDate	2025-08-25
AnnouncementXML	Submission_2025-08-24_16:05:57.330.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD065500
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	parinaz kazemi
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2025-06-26 04:07:55	ID requested
⏵ 1	2025-08-24 16:05:58	announced

Publication List

Lee E, Kazemi P, Shafiei S, Yull S, Rana M, Tawil N, Montermini L, Rak J, Dufort D, Extracellular vesicles as prospective biological indicators for midgestational placental complications in the mouse. Front Cell Dev Biol, 13():1636335(2025) [pubmed]
10.6019/PXD065500;
10.3389/fcell.2025.1636335;

Lee E, Kazemi P, Shafiei S, Yull S, Rana M, Tawil N, Montermini L, Rak J, Dufort D, Extracellular vesicles as prospective biological indicators for midgestational placental complications in the mouse. Front Cell Dev Biol, 13():1636335(2025) [pubmed]

10.6019/PXD065500;

10.3389/fcell.2025.1636335;

Keyword List

submitter keyword: Placenta,Mouse, Nodal, Knockout, Proteomics, EVs

submitter keyword: Placenta,Mouse, Nodal, Knockout, Proteomics, EVs

Contact List

Daniel Dufort
contact affiliation	Research Institute of the McGill University Health Centre, Montreal, QC, Canada
contact email	daniel.dufort@mcgill.ca
lab head
parinaz kazemi
contact affiliation	Research Institute of the McGill University Health Centre, Montreal, QC, Canada
contact email	parinaz.kazemi@mail.mcgill.ca
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/08/PXD065500
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/08/PXD065500

PRIDE project URI

Repository Record List

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