PXD065438 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | CSF and brain proteomics of Trem2-mKate2 KI/wt.APPSAA/SAA.hTfR KI/KI mice |
| Description | Triggering receptor expressed on myeloid cells 2 (TREM2) is a central regulator of microglial activity and loss-of-function coding variants are major risk factors for late onset Alzheimer’s disease (LOAD). To better understand the molecular and functional changes associated with TREM2 signalling in microglia, we generated a TREM2 reporter mouse model. Experimental mice expressed the reporter heterozygous while AppSAA and the hTfR knock-in were homozygous (Trem2-mKate2 KI/wt.APPSAA/SAA.hTfR KI/KI) and were treated with the antibody transport vehicle coupled TREM2 agonist antibody ATV:4D9. After the treatment CSF and brain samples were colleceted for proteomics analyses. |
| HostingRepository | PRIDE |
| AnnounceDate | 2025-12-08 |
| AnnouncementXML | Submission_2025-12-08_09:52:04.718.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Stephan Mueller |
| SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090; |
| ModificationList | acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
| Instrument | timsTOF Pro; Orbitrap Exploris 480 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-06-25 06:49:09 | ID requested | |
| ⏵ 1 | 2025-12-08 09:52:05 | announced | |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Alzheimer's disease, CSF, mouse,brain, Trem2, antibody treatment |
Contact List
| Dr. Stefan F. Lichtenthaler |
|---|
| contact affiliation | DZNE Munich, Neuroproteomics, Feodor-Lynen-Str. 17, 81377 München, Germany |
| contact email | stefan.lichtenthaler@dzne.de |
| lab head | |
| Stephan Mueller |
|---|
| contact affiliation | DZNE Munich Neuroproteomics |
| contact email | stephan.mueller@dzne.de |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
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| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD065438
- Label: PRIDE project
- Name: CSF and brain proteomics of Trem2-mKate2 KI/wt.APPSAA/SAA.hTfR KI/KI mice
