PXD065388-1
PXD065388 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Defective Olfactomedin-2 connects adipocyte dysfunction to obesity |
| Description | Olfactomedin-2 (OLFM2) is a pleiotropic glycoprotein emerging as a regulator of energy homeostasis. We here show the expression of OLFM2 to be adipocyte-specific and inversely associated with obesity. OLFM2 levels increase during adipocyte differentiation and are suppressed in inflamed adipocytes. Functionally, OLFM2 deficiency impairs adipogenesis, while its over-production enhances the transformation of fat cell progenitors. Loss and gain of function experiments revealed that OLFM2 modulates key metabolic and structural pathways, including PPAR signaling, citrate cycle, fatty acid degradation, axon guidance and focal adhesion. On the molecular level, OLFM2 deficiency in adipocytes predominantly downregulates genes involved in cell cycle. Extending these findings in vivo, both whole-body Olfm2 knockout and adipose-specific Olfm2 depletion resulted in impaired adipose cell cycle gene expression, with the latter also displaying fat mass accretion and metabolic dysfunction. Collectively, our results underscore a critical role for OLFM2 in adipocyte biology, and support a causative link between reduced adipose OLFM2 and the pathophysiology of obesity. |
| HostingRepository | MassIVE |
| AnnounceDate | 2025-07-08 |
| AnnouncementXML | Submission_2025-07-08_04:08:50.029.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Witold Szymanski |
| SpeciesList | scientific name: Mus musculus; common name: house mouse; NCBI TaxID: 10090; |
| ModificationList | Carbamidomethyl; Acetyl |
| Instrument | timsTOF Ultra; Orbitrap Eclipse |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-06-24 03:26:16 | ID requested | |
| ⏵ 1 | 2025-07-08 04:08:50 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: dia, mouse, TimsTof Ultra, Dia-NN, uPAC, autonomics, DatasetType:Proteomics |
Contact List
| Francisco J. Ortega, Ph.D. | |
|---|---|
| contact affiliation | Institut d'Investigacio Biomedica de Girona (IDIBGI) |
| contact email | fortega@idibgi.org |
| lab head | |
| Witold Szymanski | |
| contact affiliation | Philipps-University Marburg Biochemical/Pharmacological Center Department of Medicine |
| contact email | witold.szymanski@uni-marburg.de |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v10/MSV000098300/ |
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