PXD065368-1

PXD065368 is an original dataset announced via ProteomeXchange.

Title	Alphavirus M1 disrupts super-enhancer-driven oncogenic transcription in osteosarcoma
Description	This dataset includes tandem mass tag (TMT)-based quantitative proteomics and immunoprecipitation-mass spectrometry (IP-MS) data derived from osteosarcoma cells infected with the oncolytic M1 virus. The proteomic analysis was performed to identify differential protein expression, focusing on changes in super-enhancer-associated transcriptional regulators, particularly RNA polymerase II subunit RPB1. The IP-MS dataset captures interacting proteins of RPB1 and viral non-structural protein NSP2, aiming to uncover the mechanism by which NSP2 mediates CUL2 E3 ligase complex recruitment and promotes RPB1 ubiquitination and degradation. These data support the mechanistic findings presented in the manuscript titled “Alphavirus M1 disrupts super-enhancer-driven oncogenic transcription via non-structural protein NSP2 in osteosarcoma.“
HostingRepository	iProX
AnnounceDate	2025-06-23
AnnouncementXML	Submission_2026-03-01_17:52:02.134.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jiajun Zhang
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2025-06-23 20:38:49	ID requested
⏵ 1	2026-03-01 17:52:02	announced

Dataset with its publication pending

submitter keyword: Alphavirus M1, Super-enhancer, Osteosarcoma

Jingnan Shen
contact affiliation	The First Affiliated Hospital of Sun Yat-Sen University
contact email	shenjn@mail.sysu.edu.cn
lab head
Jiajun Zhang
contact affiliation	The First Affiliated Hospital of Sun Yat-Sen University
contact email	zhangjiajun92@126.com
dataset submitter

iProX dataset URI