PXD065365 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | 2E7 Antigen Identification Using PhAbomics Technology |
| Description | Antibody–drug conjugates (ADCs) require antibodies with both high specificity and efficient internalization—features often overlooked by conventional discovery pipelines that rely on preselected antigens and recombinant proteins. Here, we present an integrated phenotypic platform that combines target-unbiased live-cell biopanning with in situ chemical crosslinking and mass spectrometry to concurrently identify internalizing 49 antibodies and their membrane-bound cognate antigens in a physiologic context. |
| HostingRepository | PRIDE |
| AnnounceDate | 2025-11-20 |
| AnnouncementXML | Submission_2025-11-20_01:48:14.907.xml |
| DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD065365 |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Eugene YI |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
| Instrument | Q Exactive |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-06-23 20:08:20 | ID requested | |
| ⏵ 1 | 2025-11-20 01:48:15 | announced | |
Publication List
Keyword List
| submitter keyword: Antibody, Antigen, Cell-based Antibody Panning |
Contact List
| Eugene C |
|---|
| contact affiliation | Seoul National University |
| contact email | euyi@snu.ac.kr |
| lab head | |
| Eugene YI |
|---|
| contact affiliation | Seoul National University |
| contact email | tcpl.mmbs@gmail.com |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/11/PXD065365 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD065365
- Label: PRIDE project
- Name: 2E7 Antigen Identification Using PhAbomics Technology
