PXD065331-1

PXD065331 is an original dataset announced via ProteomeXchange.

Title	Impact of Diabetes and CKD Comorbidity on Cardiac Mitochondrial function, Oxidative Stress, and Structural Remodeling
Description	Both diabetes and chronic kidney disease (CKD) predispose individuals to cardiac remodeling and coronary microvascular dysfunction. Our previous studies in swine models have revealed significant alterations in microvascular and myocardial structure and function, along with increased oxidative stress. In the present study, we aim to delineate the effects of diabetes alone and to investigate the combined impact of diabetes and CKD on cardiac performance.
HostingRepository	PRIDE
AnnounceDate	2026-01-23
AnnouncementXML	Submission_2026-01-23_01:46:09.823.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jan Bernd Stöckl
SpeciesList	scientific name: Sus scrofa domesticus (domestic pig); NCBI TaxID: NEWT:9825;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive HF-X

Revision	Datetime	Status	ChangeLog Entry
0	2025-06-23 06:29:34	ID requested
⏵ 1	2026-01-23 01:46:10	announced

Sen P, Sittig T, Hamers J, d'Ambrosio L, Ornek I, Zhang J, Shashikadze B, St, ö, ckl JB, Bachter M, Bierschenk S, Renner S, Wolf E, Clauss S, Fr, ö, hlich T, Nickel AG, Maack C, Merkus D, From kidney injury to cardiac dysfunction: the central role of oxidative stress in diabetes and CKD. Basic Res Cardiol, 121(1):93-112(2026) [pubmed]

10.1007/s00395-025-01153-6;

submitter keyword: chronic kidney disease, heart, diabetes, cardiac muscle

Thomas Fröhlich
contact affiliation	Ludwig-Maximilians-Universität München Genzentrum Laboratory for Functional Genome Analysis Feodor-Lynen-Str. 25 D-81377 München
contact email	frohlich@genzentrum.lmu.de
lab head
Jan Bernd Stöckl
contact affiliation	Genzentrum der LMU München
contact email	stoeckl@genzentrum.lmu.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/01/PXD065331

PRIDE project URI

• PRIDE
  1. PXD065331
     1. Label: PRIDE project
     2. Name: Impact of Diabetes and CKD Comorbidity on Cardiac Mitochondrial function, Oxidative Stress, and Structural Remodeling