PXD065313 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Serum proteomics of multiple menstrual symptoms in female athlete |
| Description | Menstrual symptoms, including primary dysmenorrhea and premenstrual syndrome, are significant problems affecting women’s health condition. However, their biological functions are still unclear. The objective of this study was to elucidate proteins related to menstrual symptoms with high-performance two-dimensional gel electrophoresis (2DE). Serum samples were collected once a week over five weeks. At the same time, 46 types of menstrual symptoms were evaluated using a menstrual distress questionnaire (MDQ) on a scale of 0-4 (0:no symptom, closer to 4:severe). 2DE images were obtained from the serum of participants with continuous menstrual phases, including the luteal, menstrual and follicular phases. Multiple regression analysis was conducted to identify proteins that change in response to the interaction between menstrual phase and menstrual symptoms. As a result, six symptoms were associated with specific proteins (muscle stiffness with serin protease-1; general aches and pains with junction plakoglobulin; tension with transferrin, ceruloplasmin and desmoglein; depression with kininogen-1; distractible with dermcidin; tendency to take a nap or stay in bed with transferrin and hemopexin). These results indicate that various menstrual symptoms may have different underlying mechanisms. Further research into these proteins may lead to novel understanding of menstrual symptoms and support more effective health management for women. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-04-27 |
| AnnouncementXML | Submission_2026-04-26_16:15:27.231.xml |
| DigitalObjectIdentifier | https://doi.org/10.6019/PXD065313 |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Kai Fushimi |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Exploris 480 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-06-23 00:57:07 | ID requested | |
| ⏵ 1 | 2026-04-26 16:15:28 | announced | |
Publication List
| 10.6019/PXD065313; |
| Fushimi K, Kondo T, Ikegami N, Yamada M, Wong SY, Sakamaki-Sunaga M, Hayashi N, Serum Proteomics of Multiple Menstrual Symptoms in Female Athletes: A Pilot Study. FASEB Bioadv, 8():e70109(2026) [pubmed] |
| 10.1096/fba.2026-00002; |
Keyword List
| submitter keyword: Human, Serum, LC-MS, Two-dimentional gel electrophoresis |
Contact List
| Kai Fushimi |
|---|
| contact affiliation | Department of Life Science and Technology, Graduate School of Life Science and Technology Institute of Science Tokyo |
| contact email | fushimi.k.2b47@m.isct.ac.jp |
| lab head | |
| Kai Fushimi |
|---|
| contact affiliation | Tokyo Institute of Technology, Grd of Life science and technology |
| contact email | fushimi.k.2b47@m.isct.ac.jp |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD065313 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD065313
- Label: PRIDE project
- Name: Serum proteomics of multiple menstrual symptoms in female athlete
