PXD065274 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | MS analyses of mouse VLDL from WT and ApoA5 (Apolipoprotein A-V) knockout mice |
| Description | The impact of APOA5 on VLDL composition and its potential to alter VLDL metabolism in other ways remains poorly understood. To address this, we investigated the influence of APOA5 on the VLDL proteome. We used VLDL from Apoa5 knockout (KO) and wild-type (WT) mice, for mass spectrometry utilizing two independent laboratories. We identified consistent depletion of 17 proteins involved in lipoprotein metabolism, inflammation, and immune response in Apoa5 KO VLDL, including APOE and serum amyloid A1 (SAA1). |
| HostingRepository | PRIDE |
| AnnounceDate | 2025-11-24 |
| AnnouncementXML | Submission_2025-11-23_16:24:37.704.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Pheruza Tarapore |
| SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive HF; Orbitrap Fusion Lumos |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-06-20 09:50:10 | ID requested | |
| ⏵ 1 | 2025-11-23 16:24:38 | announced | |
Publication List
| 10.1016/j.jlr.2025.100917; |
| Tarapore P, Swertfeger D, Morris J, He Y, Sarkar S, Melchior JT, Shah AS, Liu M, Davidson WS, Apolipoprotein A5 reduces clearance of VLDL by altering apolipoprotein E content. J Lipid Res, 66(11):100917(2025) [pubmed] |
Keyword List
| submitter keyword: mouse, knockout, VLDL, apolipoprotein A-V |
Contact List
| W. Sean Davidson |
|---|
| contact affiliation | Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, OH, USA |
| contact email | davidswm@ucmail.uc.edu |
| lab head | |
| Pheruza Tarapore |
|---|
| contact affiliation | University of Cincinnati |
| contact email | tarapopp@ucmail.uc.edu |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/11/PXD065274 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD065274
- Label: PRIDE project
- Name: MS analyses of mouse VLDL from WT and ApoA5 (Apolipoprotein A-V) knockout mice
