PXD065200-1

PXD065200 is an original dataset announced via ProteomeXchange.

Title	Naturally presented benzypenicillin-modified HLA-A*02:01 ligands
Description	This study characterised the array of benzylpenicillin-modified ligands within the immunopeptidome of HLA-A*02:01. We further describe a novel target of penicillin within the immunopeptidome and proteome. Identification of penicillin-modified ligands within the immunopeptidome will allow future immunogenicity assays to aid in understanding how T cells can mediate penicillin-induced hypersensitivities.
HostingRepository	PRIDE
AnnounceDate	2025-10-01
AnnouncementXML	Submission_2025-09-30_16:32:19.361.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD065200
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Shawn Goh
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	cysteinylation (disulfide with free L-cysteine); monohydroxylated residue; deamidated residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2025-06-18 22:57:50	ID requested
⏵ 1	2025-09-30 16:32:19	announced

10.6019/PXD065200;

10.1111/ALL.70025;

submitter keyword: Allergy, HLA, Penicillin, Beta-lactam, Immunopeptidomics, Benzylpenicillin

Anthony Wayne
contact affiliation	Deputy Head (Research), Department of Biochemistry and Molecular Biology. Head Immunoproteomics Laboratory Infection and Immunity Program Room 214, level 2, 15 Innovation Walk, Monash Biomedicine Discovery Institute, Monash University, Clayton Campus. Clayton 3800. Victoria Australia
contact email	anthony.purcell@monash.edu
lab head
Shawn Goh
contact affiliation	Monash University
contact email	shawn.goh@monash.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/10/PXD065200

PRIDE project URI

• PRIDE
  1. PXD065200
     1. Label: PRIDE project
     2. Name: Naturally presented benzypenicillin-modified HLA-A*02:01 ligands