PXD065146-1

PXD065146 is an original dataset announced via ProteomeXchange.

Title	Traditional Chinese Medicine-Colorectal cancer
Description	In this study, we implemented a high-throughput transcriptome sequencing platform integrated with machine learning-enhanced predictive analytics to systematically screen 188 medicinal plant extracts for anti-neoplastic bioactivity. Leveraging multi-layered omics interrogation—including differential gene expression profiling, weighted gene co-expression network analysis (WGCNA), and Signaling pathway enrichment—we delineated phytochemical candidates with dual targeting capacity against metastatic drivers and inflammatory mediators. Subsequent Phosphoproteomic profiling confirmed the therapeutic strategies of lead compounds. This methodology establishes a transformative paradigm for natural product drug discovery, combining next-generation sequencing with artificial intelligence-driven bioactivity prediction.
HostingRepository	iProX
AnnounceDate	2025-06-18
AnnouncementXML	Submission_2025-06-18_01:15:55.513.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Tingting Hao
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2025-06-18 01:15:41	ID requested
⏵ 1	2025-06-18 01:15:55	announced

Dataset with its publication pending

submitter keyword: Traditional Chinese Medicine,Colorectal cancer,Proteomic

Yang Dong
contact affiliation	Yunnan Agricultural University
contact email	loyalyang@163.com
lab head
Tingting Hao
contact affiliation	Yunnan Agricultural University
contact email	740267104@qq.com
dataset submitter

iProX dataset URI