PXD065109-1

PXD065109 is an original dataset announced via ProteomeXchange.

Title	A sEH/COX-2 Dual Inhibitor PTUPB Reduces Endothelium-to-Mesenchymal Transition and Improves Doxorubicin-induced Vascular and Cardiac Toxicity
Description	Doxorubicin (DOX) is an effective anthracycline agent used to combat many neoplastic diseases. However, DOX causes cardiovascular toxicity in juvenile and young adult cancer survivors that can lead to future cardiomyopathy. Thus, it is essential to address the cardiovascular toxicity caused by DOX to improve the long-term health of cancer patients. Several studies have suggested that soluble epoxide hydrolase (sEH) and cyclooxygenase-2 (COX-2) are implicated in cardiovascular diseases by impairing vascular health and promoting the transition of Endothelial cells to Mesenchymal cells (EndMT). Given the role of sEH and COX-2 in EndMT cardiovascular toxicity, we aimed to investigate the effect of a dual sEH/COX-2 inhibitor, PTUPB, on DOX-induced EndMT, vascular and cardiac toxicity. We tested the beneficial effect of PTUPB on DOX-induced cardiovascular toxicity in zebrafish.
HostingRepository	PRIDE
AnnounceDate	2025-06-25
AnnouncementXML	Submission_2025-06-25_00:00:27.276.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Hevna Dhulkifle
SpeciesList	scientific name: Danio rerio (Zebrafish) (Brachydanio rerio); NCBI TaxID: 7955;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2025-06-17 04:44:02	ID requested
⏵ 1	2025-06-25 00:00:27	announced

Dataset with its publication pending

submitter keyword: Zebrafish, Whole Protein, Doxorubicin, soluble epoxide hydrolase

Dr. Zaid
contact affiliation	Department of Pharmaceutical Sciences, College of Pharmacy, QU Health Sector, Qatar University, 2713, Doha, Qatar
contact email	almaayah@qu.edu.qa
lab head
Hevna Dhulkifle
contact affiliation	Qatar University
contact email	hd1401929@qu.edu.qa
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/06/PXD065109

PRIDE project URI

• PRIDE
  1. PXD065109
     1. Label: PRIDE project
     2. Name: A sEH/COX-2 Dual Inhibitor PTUPB Reduces Endothelium-to-Mesenchymal Transition and Improves Doxorubicin-induced Vascular and Cardiac Toxicity