PXD065044 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Bioresponsive pseudoGlucosinolates (psGSLs) release Isothiocyanates (ITCs) in the Presence of Nitroreductases |
| Description | Glucosinolates (GSLs) are secondary metabolites produced as part of an herbivore defence system in plants of the order Brassicales. GSLs release isothiocyanates (ITCs) upon activation by the myrosinase. Beyond their herbivore feeding deterrent properties, these ITCs have multiple interesting bioactivities. However, their release is limited by the presence of myrosinase. Here, we report the concept of pseudoglucosinolates (psGSLs) hijacking the natural release mechanism of GSLs for the release of ITCs and adapting it to nitroreductase as the triggering enzymes. We provide proof-of-concept for nitroreductase-responsive psGSLs and demonstrate their potential for peptide labelling, ITC-prodrug approaches and for in vivo applications using the nematode of C. elegans |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-09-07 |
| AnnouncementXML | Submission_2026-09-06_16:14:30.010.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Liisa Arike |
| SpeciesList | scientific name: synthetic construct (code 12); NCBI TaxID: NEWT:2005482; |
| ModificationList | deamidated residue; iodoacetamide derivatized residue |
| Instrument | Orbitrap Fusion Lumos |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-06-16 05:18:04 | ID requested | |
| ⏵ 1 | 2026-09-06 16:14:30 | announced | |
Publication List
| Jimidar CC, Ganskow CSG, Kagho MD, Chakrabarti A, Wiese L, Zollo M, Beutling U, Cesar LC, Morud J, Bugaj K, Br, รถ, nstrup M, Sieber SA, Hacker SM, Klahn P, Bioresponsive pseudoGlucosinolates (psGSLs) Release Isothiocyanates (ITCs) in the Presence of Nitroreductases. Chemistry, 32(25):e71012(2026) [pubmed] |
| 10.1002/chem.71012; |
Keyword List
| submitter keyword: bioresponsive molecules,pseudoGlucosinolates, artificial gluscosinolates, nitroreductase , isothiocanantes |
Contact List
| Philipp Klahn |
|---|
| contact affiliation | Department of Chemistry and Molecular Biology, University of Gothenburg, Natrium, Medicinaregatan 7B, 413 90, Gothenburg, Sweden |
| contact email | philipp.klahn@gu.se |
| lab head | |
| Liisa Arike |
|---|
| contact affiliation | PhD |
| contact email | liisaarike@gmail.com |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/09/PXD065044 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD065044
- Label: PRIDE project
- Name: Bioresponsive pseudoGlucosinolates (psGSLs) release Isothiocyanates (ITCs) in the Presence of Nitroreductases
