⮝ Full datasets listing
PXD065038-1
PXD065038 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Neuronal Idol deletion ameliorates amyloid pathology |
| Description | Earlier studies demonstrated that overexpression of the low-density lipoprotein receptor (LDLR) decreases apolipoprotein E (APOE) levels in the brain and alleviates amyloid-beta (Abeta) pathology. We hypothesized that inhibiting the Inducible Degrader of LDLR (IDOL)- an E3 ubiquitin ligase that ubiquitinates LDLR for degradation- would increase endogenous LDLR levels and decrease amyloid pathology. Previously, we demonstrated that the deletion of Idol increased LDLR levels and reduced amyloid deposition in a transgenic mouse model of Abeta-amyloidosis. However, the cellular mechanisms underlying these beneficial effects were unknown. Here, we investigate the cell-type-specific contribution of Idol deletion to amyloid pathology by generating Idol conditional knock-out mouse models. We demonstrate that deletion of neuronal, but not microglial, Idol reduces amyloid accumulation in the 5XFAD transgenic mouse model. Furthermore, only neuronal Idol deletion alters brain LDLR and APOE levels, pointing to the critical role of the neuronal LDLR-APOE axis in modulating Abeta accumulation. |
| HostingRepository | MassIVE |
| AnnounceDate | 2025-12-15 |
| AnnouncementXML | Submission_2025-12-15_23:45:51.317.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Kim Lab |
| SpeciesList | scientific name: Mus musculus; common name: house mouse; NCBI TaxID: 10090; |
| ModificationList | Phospho; TMTpro; oxidation; Carbamidomethyl; Met-loss+Acetyl; Deamidated |
| Instrument | Orbitrap Eclipse |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-06-16 02:16:47 | ID requested | |
| ⏵ 1 | 2025-12-15 23:45:51 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: Idol, APOE, LDLR, VLDLR, Reelin, Abeta, DatasetType:Proteomics |
Contact List
| Jungsu Kim | |
|---|---|
| contact affiliation | Indiana University School of Medicine |
| contact email | jk123@iu.edu |
| lab head | |
| Kim Lab | |
| contact affiliation | IUSM |
| contact email | jk123@iu.edu |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v10/MSV000098209/ |
