PXD065006 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | The Parkinson’s disease kinase LRRK2 impairs release sites of vulnerable dopamine axons -striatal synaptosomes phosphoproteomic study |
| Description | We and others previously reported that knock-in mice expressing the pathogenic hyperactive Lrrk2G2019S mutation, exhibit deficits in dopamine release within the striatum. To investigate the underlying molecular mechanisms, we conducted quantitative phosphoproteomic Liquid Chromatography-Mass Spectrometry (LC-MS) studies on striatal synaptosomes from Lrrk2G2019S mice. Mice were treated with vehicle control or the potent and specific LRRK2 kinase inhibitor MLi-2, as pharmacological inhibition of the hyperactive Lrrk2G2019S kinase increases the likelihood of identifying in vivo changes in phosphoregulation. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-05-19 |
| AnnouncementXML | Submission_2026-05-18_16:47:08.113.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Chuyu Chen |
| SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive HF |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-06-13 10:39:24 | ID requested | |
| ⏵ 1 | 2026-05-18 16:47:08 | announced | |
Publication List
| 10.1101/2025.08.28.672006; |
| Chen C, He Q, Tombesi G, Napier E, Jaconelli M, Moreno-Ramos OA, Serio H, Naaldijk Y, Promes V, Schneeweis A, Quinn K, Nasios C, Greggio E, Kozorovitskiy Y, Arango D, Khan AR, Alessi DR, Dombeck DA, Hilfiker S, Awatramani R, Parisiadou L, Leucine-rich repeat kinase 2 impairs the release sites of Parkinson's disease vulnerable dopamine axons. bioRxiv, ():(2025) [pubmed] |
Keyword List
| submitter keyword: LC-MS,LRRK2, striatal synaptosomes |
Contact List
| Loukia Parisiadou |
|---|
| contact affiliation | Department of Pharmacology, Northwestern University, Chicago, IL, USA |
| contact email | loukia.parisiadou@northwestern.edu |
| lab head | |
| Chuyu Chen |
|---|
| contact affiliation | Northwestern university |
| contact email | chuyu.chen@northwestern.edu |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD065006 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD065006
- Label: PRIDE project
- Name: The Parkinson’s disease kinase LRRK2 impairs release sites of vulnerable dopamine axons -striatal synaptosomes phosphoproteomic study
